Rumpel Learning Postsynaptic Receptor Trafficking Underlying a Form of Associative
نویسنده
چکیده
, 83 (2005); 308 Science et al. Simon Rumpel Learning Postsynaptic Receptor Trafficking Underlying a Form of Associative This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): October 2, 2013 www.sciencemag.org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/308/5718/83.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2005/03/29/1103944.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/308/5718/83.full.html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/content/308/5718/83.full.html#ref-list-1 , 25 of which can be accessed free: cites 49 articles This article 144 article(s) on the ISI Web of Science cited by This article has been http://www.sciencemag.org/content/308/5718/83.full.html#related-urls 85 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/neuroscience Neuroscience subject collections: This article appears in the following
منابع مشابه
Postsynaptic receptor trafficking underlying a form of associative learning.
To elucidate molecular, cellular, and circuit changes that occur in the brain during learning, we investigated the role of a glutamate receptor subtype in fear conditioning. In this form of learning, animals associate two stimuli, such as a tone and a shock. Here we report that fear conditioning drives AMPA-type glutamate receptors into the synapse of a large fraction of postsynaptic neurons in...
متن کاملConversion of silent synapses into the active pool by selective GluR1-3 and GluR4 AMPAR trafficking during in vitro classical conditioning.
The conversion of silent synapses into active sites is hypothesized to be a primary mechanism underlying learning and memory processes. Here we used an in vitro model of classical conditioning from turtles that demonstrates a neural correlate of eyeblink conditioning to examine whether the conversion of silent synapses has a role in this form of associative learning. This was accomplished by di...
متن کاملLong-term modifications in the strength of excitatory associative inputs in the piriform cortex.
Afferent olfactory information, in vivo and in vitro, can be rapidly adapted to through a metabotropic glutamate receptor (mGluR)-mediated attenuation of synaptic strength. Specific cellular and synaptic mechanisms underlying olfactory learning and habituation at the cortical level remain unclear. Through whole-cell recording, excitatory postsynaptic currents (EPSCs) were obtained from piriform...
متن کاملInvolvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice.
Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded the functional changes taking place at the hippocampal CA3-CA1 synapse during the acquisition of ...
متن کاملLearning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics.
Neuronal plasticity is an important process for learning, memory and complex behaviour. Rapid remodelling of the actin cytoskeleton in the postsynaptic compartment is thought to have an important function for synaptic plasticity. However, the actin-binding proteins involved and the molecular mechanisms that in vivo link actin dynamics to postsynaptic physiology are not well understood. Here, we...
متن کامل